U.S. POINTER Results Show That Healthy Behaviors

Have a Powerful Impact on Brain Health

This two-year clinical trial found that simultaneously targeting risk factors for cognitive decline – including regular physical activity, a brain-healthy diet, cognitive and social engagement and health monitoring – can improve brain function in older adults.

While the cognitive health of all participants in U.S. POINTER improved, the group* that followed a more structured program improved even more, helping to protect thinking and memory from the normal decline that often comes with aging over the two-year period of the study. These results provide powerful, actionable guidance for promoting brain health in aging populations.

Learn more at alz.org/uspointer

“Effects Of Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The U.S. POINTER Randomized Clinical Trial,” was published in The Journal of the American Medical Association (JAMA) on July 28, 2025 and simultaneously presented at the Alzhei- mer’s Association International Conference® (AAIC®)